Normative Data of Handgrip Strength in Macedonian Children and Adolescents According to Chronological and Biological Age / Datos Normativos de la Fuerza de Prensión Manual en Niños y Adolescentes Macedonios Según la Edad Cronológica y Biológica

SUMMARY: The handgrip strength is used as a means of individual's health prediction during life. It is used as an indicator of the nutrition status, bone fragility, presence of sarcopenia and it correlates with certain diseases and clinical complications. The research goal was to analyze the results of the hand dynamometry test, based on the chronological and biological age, and to offer normative and referent standards about children and adolescents from the Republic of North Macedonia. The study was conducted on a sample of 4031 respondents of both sexes at the age 6-14 years. In order to achieve the research goals, the measured characteristics were of the weight, height, sitting height and handgrip strength. The body mass index and biological maturity values (APHV) were obtained by using formulas. On the basis of the obtained results, it can be concluded that statistically significant differences in handgrip strength are established between the boys and girls of all age categories. Also, statistically significant differences between boys and girls are established in the hand dynamometry test of all APHV levels. In general, the use of the APHV allows a better categorization of the performance of the studied children and adolescents. With boys, the correlation between the chronological age and test was 68 %, and with girls - 77 %. The normative referent standards of the hand dynamometry test are presented in percentiles for both sexes. Thye hand dynamometry test's results during childhood and adolescence should be analyzed and interpret on the basis of biological age, and not on the chronological age. These tools can help specialists who work with children and adolescents in ethnic and epidemiological context.

La fuerza de prensión se utiliza como medio para predecir la salud del individuo durante la vida. Se utiliza como indicador del estado nutricional, fragilidad ósea, presencia de sarcopenia y se correlaciona con determinadas enfermedades y complicaciones clínicas. El objetivo de la investigación fue analizar los resultados de la prueba de dinamometría manual, con base en la edad cronológica y biológica, y ofrecer estándares normativos y referentes sobre niños y adolescentes de la República de Macedonia del Norte. El estudio se realizó en una muestra de 4031 encuestados de ambos sexos con edades comprendidas entre 6 y 14 años. Para lograr los objetivos de la investigación, las características medidas fueron el peso, la altura, la altura al sentarse y la fuerza de prensión. El índice de masa corporal y los valores de madurez biológica (APHV) se obtuvieron mediante fórmulas. Sobre la base de los resultados obtenidos, se puede concluir que se establecen diferencias estadísticamente significativas en la fuerza de prensión manual entre niños y niñas de todas las categorías de edad. Asimismo, se establecen diferencias estadísticamente significativas entre niños y niñas en la prueba de dinamometría manual de todos los niveles APHV. En general, el uso del APHV permite una mejor categorización del desempeño de los niños y adolescentes estudiados. En los niños, la correlación entre la edad cronológica y la prueba fue del 68 %, y en las niñas, del 77 %. Los estándares normativos referentes de la prueba de dinamometría manual se presentan en percentiles para ambos sexos. Los resultados de la prueba de dinamometría manual durante la infancia y la adolescencia deben analizarse e interpretarse en función de la edad biológica y no de la edad cronológica. Estas herramientas pueden ayudar a los especialistas que trabajan con niños y adolescentes en un contexto étnico y epidemiológico.

Maturation and development of fetal pig intestinal tissue in immunodeficient mice

Purpose: This study aimed to compare the degree of maturation and development of fetal pig segmental intestinal tissue with that of spheroids created by in-vitro reaggregation of dissociated fetal intestinal cells after transplantation into immunodeficient mice. Methods: Fetal pig small intestines were transplanted as segmental grafts into the omentum and subrenal capsules of immunodeficient mice or enzymatically treated to generate single cells. Spheroids made by in-vitro reaggregation of these cells were transplanted into the subrenal capsules of immunodeficient mice. The segmental grafts and spheroids were harvested four and eight weeks after transplantation, and the structural maturity and in-vivo development of these specimens were histologically evaluated. Results: The spheroids were engrafted and supplied blood vessels from the host mice, but an intestinal layered structure was not clearly observed, and there was almost no change in size. On the other hand, the segmental grafts formed deep crypts in the mucus membrane, the inner circular layer, and outer longitudinal muscles. The crypts of the transplanted grafts harvested at eight weeks were much deeper, and the smooth muscle layer and the enteric nervous system were more mature than those of grafts harvested at the fourth week, although the intestinal peristaltic wave was not observed. Conclusions: Spheroids created from fetal small intestinal cells could not form layered structures or mature sufficiently. Conversely, segmental tissues structurally matured and developed after in-vivo transplantation and are therefore potential grafts for transplantation.

IMPACT OF LEADER'S INVOLVEMENT IN AGILE MATURITY ASSESSMENTS

Agile is the way we look at things happening around us. Agile is a behavior pattern, how you look at the world's complex situations, how you react to situations, how you visualize a solution, how you reach the solution. You can either think of a complex problem or a situation and worry about it or you break that into meaningful small chinks & try to solve it. Agile adds that fun element of tackling smaller challenges systematically. As we move from the traditional hierarchical working to self-managing and agility, it is evident for teams to see the radical shift in people's day-to-day behaviors. These new ways of working bring in an increased sense of ownership, proactive, open communication, accepting failures, and more importantly trust and transparency among team members. Agile maturity assessments are tools or processes used to evaluate and measure an organization's or team's level of agility and their effectiveness in implementing Agile principles and practices. These assessments help identify areas of strength and improvement, enabling organizations to enhance their Agile adoption and transformation journey

Testicular Volume of Boys Aged 5-17 Years in Relation to Sexual Maturity Rating and Clinical Onset of Puberty in an Urban Setting in Gujarat, India

Background : Assessment of Sexual Maturity Rating and Testicular Volume are indispensable in the routine assessment of puberty in boys. There is paucity of data in Indian population for Testicular Volume particularly in early adolescence. Aims : The aims of the study were to collect data for testicular volume,correlate testicular volume with Sexual Maturity Rating (SMR) and the clinical onset of puberty; and to identify Testicular abnormalities in boys aged 5 to 17 years in an Urban setting in Gujarat, India. Materials and Methods : A prospective observational study was undertaken in boys aged5 to 17years of age from Gujarat from April, 2019 to August, 2019. Mean Testicular Volume was measured with a Prader抯 orchidometer. Parameters like Age, Weight and Height were also measured and Body Mass Index (BMI) was calculated. Pubertal stage was categorized using Tanner staging. Data was statistically analyzed using Microsoft Excel and SPSS software. Results : 977 boys were included in the study. Mean age at SMR stage 2 was 11.22 years. SMR stage 2 was earliest seen at 6 years and latest at 15 years of age. 15% of boys in pre-adolescence, 60% in early adolescence and 94% in middle adolescence showed changes of Puberty. Precocious puberty was detected in 33 boys (3.38%). Delayed Puberty was detected in 4 boys (0.4%) and Undescended Testes in 4 boys (0.4%). Testicular Volume showed positive correlation with Weight, Height and BMI.

Fat-free mass and maturity status are determinants of physical fitness performance in schoolchildren and adolescents

Abstract Objectives: The objective of the study was to verify whether (FFM), maturity status (MS) and chronological age (CA) are determinants of physical fitness performance, and to analyze FFM and physical performance aligned by CA and MS in children and adolescents. Methods: A descriptive correlational study was carried out in 863 schoolchildren. Weight, height, and waist circumference (WC) were evaluated. Body mass index (BMI), FFM, fat mass (FM), MS (Age at peak height velocity, APHV) were calculated. The physical tests of velocity 20 m, agility 5 m × 10rep, and horizontal jump (HJ) were evaluated. Results: The APHV was estimated in boys at 14.0 ± 0.36APHV and in girls at 11.96 ± 0.49APHV. The relationships between CA and APHV with FFM was r = 0.80 in boys and r = 0.44 to 0.45 in girls. The relationships between FFM and physical tests in boys were [HJ (r = 0.70), agility 5m × 10rep (r = -0.68), velocity (r = -0.61)] and in girls [HJ (r = 0.42), agility 5m × 10rep (r = -0.52), velocity (r = -0.20)]. The differences in FFM and physical fitness tests were more pronounced when aligned by APHV than by CA. Conclusion: It was verified that both FFM, CA, and APHV are determinants of physical fitness performance. In addition, the APHV should be introduced in physical education as a means of ranking physical performance among schoolchildren.

Análise de Maturidade em Gestão do Conhecimento na Secretaria Municipal de Saúde da Prefeitura do município de Contagem, Minas Gerais, Brasil / Analysis of Maturity in Knowledge Management at the Municipal Health Department of the Municipality of Contagem, Minas Gerais, Brazil

O objetivo desta pesquisa foi analisar o nível de maturidade de Gestão do Conhecimento na Secretaria Municipal de Saúde da Prefeitura do município de Contagem, Minas Gerais, Brasil, aliando teoria e prática. A maturidade em Gestão do Conhecimento é estabelecida em 13 dimensões, que devem ser consideradas concomitantemente. Os métodos utilizados consistem na aplicação de um instrumento de pesquisa constituído por 39 afirmativas, dispostas em escala likert de cinco pontos, seccionadas em 13 constructos, os quais são analisados sob a ótica positivista, por meio dos critérios de Kaiser-Meyer-Olkin para dimensionalidade, Alfa de Cronbach para confiabilidade e r de Pearson junto ao p-Valor para validade, sendo adotadas Médias, Desvio Padrão e Intervalo de Confiança de 95 porcent. Os resultados indicam que a instituição se encontra no nível três de cinco, denominado Incipiente, caracterizado por buscar gerenciar o conhecimento e suas áreas críticas para seu sucesso. Para elevação ao nível quatro de cinco de maturidade, são sugeridas três ações para as dimensões, Estratégia, Liderança e suporte da Alta Administração, Equipe de Gestão do Conhecimento, Recursos (financeiro, humano, material e tempo), Processos e Atividades, Gestão de Recursos Humanos, Treinamento e Educação, Motivação, Trabalho em Equipe, Cultura, Mensuração e Projeto Piloto e duas ações para a dimensão Tecnologia da Informação, totalizando 38 ações para promoção da maturidade. Esta pesquisa contribuiu na busca por estudos empíricos sobre nível de maturidade de Gestão do Conhecimento e instiga novos estudos em diferentes instituições públicas(AU)

El objetivo de esta investigación fue analizar el nivel de madurez de la Gestión del Conocimiento en la Secretaría Municipal de Salud del Municipio de Contagem, Minas Gerais, Brasil, combinando teoría y práctica. La madurez en Gestión del Conocimiento se establece en 13 dimensiones, las cuales deben ser consideradas concomitantemente. Los métodos utilizados consisten en la aplicación de un instrumento de investigación que consta de 39 enunciados, ordenados en una escala tipo Likert de cinco puntos, seccionados en 13 constructos, los cuales son analizados desde una perspectiva positivista, utilizando los criterios de dimensionalidad de Kaiser-Meyer-Olkin; Alfa de Cronbach para la confiabilidad y r de Pearson junto con el valor-p para validez; se adopta el análisis de la media, la desviación estándar y el intervalo de confianza del 95 por ciento. Los resultados indican que la institución se encuentra en el nivel tres de cinco, denominado incipiente, caracterizado por buscar gestionar el conocimiento y sus áreas críticas en función de su éxito. Para la elevación al nivel cuatro de cinco de madurez se sugieren tres acciones para las dimensiones: estrategia, liderazgo y apoyo a la alta dirección, equipo de gestión del conocimiento, recursos (económicos, humanos, materiales y de tiempo), procesos, actividades, recursos humanos, capacitación y educación, motivación, trabajo en equipo, cultura, medición y proyecto piloto; además dos acciones para la dimensión de Tecnologías de la Información. Se proponen 38 acciones en total para promover la madurez. Esta investigación contribuyó a la búsqueda de estudios empíricos sobre el nivel de madurez de la Gestión del Conocimiento y propone nuevos estudios en diferentes instituciones públicas(AU)

The objective of this research was to analyze the maturity level of Knowledge Management in the Municipal Health Department of the Municipality of Contagem, Minas Gerais, Brazil, combining theory and practice. Maturity in Knowledge Management is established in 13 dimensions, which must be considered concomitantly. The methods used consist of the application of a research instrument consisting of 39 statements, arranged on a five-point Likert scale, sectioned into 13 constructs, which are analyzed from a positivist perspective, using the Kaiser-Meyer-Olkin criteria for dimensionality. , Cronbach's Alpha for reliability and Pearson's r together with the p-Value for validity, adopting Means, Standard Deviation and Confidence Interval of 95percent. The results indicate that the institution is at level three out of five, called Incipient, characterized by seeking to manage knowledge and its critical areas for its success. For elevation to level four out of five of maturity, three actions are suggested for the dimensions, Strategy, Leadership and Senior Management support, Knowledge Management Team, Resources (financial, human, material and time), Processes and Activities, Human Resources, Training and Education, Motivation, Teamwork, Culture, Measurement and Pilot Project and two actions for the Information Technology dimension, totaling 38 actions to promote maturity. This research contributed to the search for empirical studies on the maturity level of Knowledge Management and instigates new studies in different public institutions(AU)

Madurez neuropsicológica en niños bilingües y monolingües de zonas urbanas y rurales de la región Arequipa

Introducción: Diversos estudios han planteado que el bilingüismo favorece el desarrollo de las funciones neuropsicológicas, mientras que también se ha demostrado que, en los países de América Latina, los niños que viven en zonas urbanas presentan mayor nivel de desarrollo neuropsicológico que sus pares de zonas rurales. Objetivo: Comparar la madurez neuropsicológica en niños y niñas que viven en zonas rurales y urbanas de Arequipa (Perú), en función del sexo, la zona de residencia y el bilingüismo. Sujetos y métodos: Se evaluó a 140 niños (52.8% varones y 47.2% mujeres) con una edad promedio de 76 meses, 50% monolingües y 50% bilingües, 50% viven en zonas urbanas y 50% en zonas rurales. Se aplicó el Cuestionario de Madurez Neuropsicológica Infantil (CUMANIN) de Portellano et al. (2000). Resultados: El cociente de madurez neuropsicológica se ubica en un nivel medio alto en la muestra general. Las niñas presentan mayor nivel de estructuración espacial y madurez neuropsicológica que los niños. Los niños bilingües tuvieron un mejor rendimiento en lenguaje expresivo en comparación con los monolingües con un tamaño de efecto moderado, y los niños que residen en zonas urbanas tienen puntuaciones mayores en fluidez verbal, lectura y escritura que los de zonas rurales, con diferencias significativas y tamaños del efecto grandes. Conclusiones: La zona de residencia es determinante en el desarrollo neuropsicológico de niños bilingües y monolingües, a favor de los que provienen de zonas urbanas en funciones tales como fluidez verbal, lectura y escritura.

Introduction: Several studies have suggested that bilingualism favors development of neuropsychological functions. In addition, it has also been shown, in Latin American countries, children living in urban areas have a higher level of neuropsychological development than their peers who live in rural areas. Objective: To compare the neuropsychological maturity in boys and girls who live in rural and urban areas of Arequipa (Peru), according to sex, area of residence, and bilingualism. Subjects and methods: 140 children were evaluated (52.8% male and 47.2% female) with an average age of 76 months, 50% monolingual and 50% bilingual, 50% living in urban areas and 50% in rural areas. The Childhood Neuropsychological Maturity Questionnaire (CUMANIN) of Portellano et al. (2000) was used. Results: The neuropsychological maturity quotient is located at a high average level in the general sample. Girls presented a higher level of spatial structuring and neuropsychological maturity than boys. Bilingual children had a better performance in expressive language compared to monolinguals with a moderate effect size. Moreover, children residing in urban areas have higher scores in verbal fluency, reading and writing than those in rural areas, with significant differences and sizes of the big effect. Conclusions: The area of residence is determinant in the neuropsychological development of bilingual and monolingual children, in favor of those who come from urban areas in functions such as verbal fluency, reading and writing.

Clinical and genetic analysis of five pedigree with maturity-onset diabetes of the young type 2 / 中华内分泌代谢杂志

Objective:To explore the clinical and molecular genetic characteristics of patients with maturity-onset diabetes of the young type 2(MODY2).Methods:Clinical data and laboratory results were collected from five MODY2 patients and their family members diagnosed in the Department of Endocrinology, Genetics, and Metabolism of Xi ′an Children′s Hospital in the recent two years. Whole exome sequencing was carried out on every proband to identify potential variants, then the suspected variants were verified with Sanger sequencing in family numbers.Results:Among the 5 probands, except for proband 4 who presented with polydipsia and polyuria, hyperglycemia in the rest of the children was accidentally identified. Urine routine, urinary protein, and blood lipid of the five probands were all normal, and HbA 1C was between 5.96% and 8.15%. Moreover, an important discovery in this study was that proband 5 had insulin resistance(IRS), which was different from previous studies. It was confirmed by genetic analysis that a glucokinase(GCK) gene variant existed in every MODY2 pedigree. There were four GCK variants in this study, including c. 146C>T(p.T49I), c. 1237T>G(p.Y413D), c. 683C>T(p.T228M) and c. 952G>T(p.G318W), among which the C. 1237T>G(P.y413d) and C. 952G>T(P.G318W) had not been reported till now. All probands received lifestyle intervention, and the blood glucose control was relatively stable. Conclusion:There is MODY2 patient complicated with IRS. MODY2 patients can be controlled well by lifestyle interventions. In addition, we discovered two novel variants of GCK, which extend the mutation spectrum of this gene.

Third Molar Maturity Index as an Efficient Tool for Prediction of Age in a Sample Indian Population - A Retrospective Study

Introduction: The age of 18 years is an important milestone for legal matters, and developmental parameters of teeth are often used for estimation of this age. The aim of this study is to assess the efficiency of third molar maturity index (I3M) in establishing age of 18 years in Dakshina Kannada population. Methods: A total of 700 orthopantomograms were retrieved from the archives of the radiology department of Manipal College of Dental Sciences, Mangalore. The length and the width of the open apex of the mandibular left third molar was assessed using Image J software and the Third molar maturity Index (I3M) was calculated and correlated with the age of the individual. Results: Receiver operating characteristic (ROC) curve analysis showed the Area under curve of 0.94 and 0.96 in females and males, respectively, for prediction of age of 18 years. The cut?off of 0.08 predicted the 18?year cut?off with 97% specificity and 90.2% negative predictive value. The percentage of the accuracy was 80.23% if the I3M was <0.08. Conclusion: The efficiency of the cut?off of 0.08 of I3M has been tested in various population including Kosovar, Peruvian, South Indian, Libyan, Montenegro, Croatian, African (Botswana), Albanian, and Serbian. Our study also shows the efficiency of the same in South Indian Dakshina Kannada population.

Bone Age Assessment from Lateral Cephalograms Using Deep Learning Algorithms in the Indian Population

Purpose: The assessment of bone age has applications in a wide variety of fields: from orthodontics to immigration. The traditional non?automated methods are time?consuming and subject to inter? and intra?observer variability. This is the first study of its kind done on the Indian population. In this study, we analyse different pre?processing techniques and architectures to determine the degree of maturation (i.e. cervical vertebral maturation [CVM]) from cephalometric radiographs using machine learning algorithms. Methods: Cephalometric radiographs—labelled with the correct CVM stage using Baccetti et al. method—from 383 individuals aged between 10 and 36 years were used in the study. Data expansion and in?place data augmentation were used to handle high data imbalances. Different pre?processing techniques like Sobel filters and canny edge detectors were employed. Several deep learning convolutional neural network (CNN) architectures along with numerous pre?trained models like ResNet?50 and VGG?19 were analysed for their efficacy on the dataset. Results: Models with 6 and 8 convolutional layers trained on 64 × 64–size grayscale images trained the fastest and achieved the highest accuracy of 94%. Pre?trained ResNet?50 with the first 49 layers frozen and VGG?19 with 10 layers frozen to training had remarkable performances on the dataset with accuracies of 91% and 89%, respectively. Conclusions: Custom deep CNN models with 6–8 layers on 64 × 64–sized greyscale images were successfully used to achieve high accuracies to classify the majority classes. This study is a launchpad in the development of an automated method for bone age assessment from lateral cephalograms for clinical purposes.

Relación del crecimiento sagital de los maxilares y el índice de maduración cervical / Relationship between the sagittal growth of the maxillary and the cervical maturation index

Resumen El crecimiento del maxilar se manifiesta de manera diferente respecto a la mandíbula, la cual se caracteriza por un desarrollo sagital más tardío. El objetivo de esta investigación fue asociar el crecimiento sagital del maxilar superior e inferior con el índice de maduración cervical en radiografías cefálicas laterales de pacientes entre 8 a 20 años de la ciudad de Cuenca, Ecuador. Se realizó una investigación con enfoque cuantitativo de tipo descriptivo, correlacional y de corte transversal retrospectivo, con una base de datos de 10.586 radiografías cefálicas laterales. Se observó que el pico de crecimiento inicia alrededor de los 9 años en las mujeres y en los hombres a los 11 años, y este culmina a los 13 años en el sexo femenino y entre los 14 y 17 años en el sexo masculino. Además, se determinó una correlación baja ente el crecimiento sagital del maxilar superior y los estadios de maduración vertebral (r=0,338) así como con el maxilar inferior (r= 0,357). Finalmente, se concluyó que el crecimiento del maxilar superior se produce en los primeros estadios de maduración cervical, mientras que en el maxilar inferior el crecimiento longitudinal se produce a partir del estadio III de maduración cervical.

Abstract The growth of the maxilla manifests itself differently from the mandible, which is characterized by a later sagittal development. The objective of the research was to associate the sagittal growth of the upper and lower jaw and the cervical maturation index in lateral cephalic radiographs of patients between 8 and 20 years of age from the city of Cuenca. A descriptive, correlational and retrospective cross-sectional quantitative approach was conducted with a database of 10,586 lateral cephalic radiographs. It was observed that the peak of growth begins around 9 years of age in women and at 11 years in men, and culminates at age 13 in females, and between 14 and 17 years in males. In addition, a low correlation was determined between the sagittal growth of the upper jaw and the stages of vertebral maturation (r = 0.338) as well as with the lower jaw (r = 0.357). Finally, it was concluded that the growth of the upper jaw occurs in the first stages of cervical maturation, while in the lower jaw, longitudinal growth occurs from stage III of cervical maturation.

Advanced Scoring and Interpretation of Vineland Social Maturity Scale: Procedure to obtain 'Impairment Adjusted Social Quotient

Vineland Social Maturity Scale (VSMS) is generally used to determine three related but different aspects, which is (i) social and adaptive functions, (ii) level of disability and (iii) intelligence. Despite having different uses or despite being used for different purposes, VSMS has been administered, scored and interpreted in a similar way, which many times can lead to erroneous results. When VSMS is used to assess intelligence in children with autism, speech, hearing and other impairments, the very symptoms these children have (such as ‘not playing with peers’, ‘not able to talk’, ‘not interested to read’) can pull down their SQ (IQ) score, which adversely affects these children in different ways. To overcome such limitations, the current article proposes a procedure, where particular items (symptoms) that pulls down the SQ (IQ) score are completely omitted from scoring calculations. This procedure overcomes a major limitation in the assessment of intelligence (that has existed from decades), especially for those children, for whom, no other tests could be carried out except VSMS. Hence, this procedure can benefit thousands of children, families, special education teachers, mental health and other professionals who work with children.

When do we need to suspect maturity onset diabetes of the young in patients with type 2 diabetes mellitus?

ABSTRACT Objetivo: Maturity onset diabetes of the young (MODY) patients have clinical heterogeneity as shown by many studies. Thus, often it is misdiagnosed to type 1 or type 2 diabetes(T2DM). The aim of this study is to evaluate MODY mutations in adult T2DM patients suspicious in terms of MODY, and to show clinical and laboratory differences between these two situations. Subjects and methods: In this study, we analyzed 72 type 2 diabetic patients and their relatives (35F/37M) who had been suspected for MODY and referred to genetic department for mutation analysis. The gene mutations for MODY have been assessed in the laboratory of Marmara University genetics. Totally 67 (32F/35M; median age 36.1) diabetic patients were analyzed for 7 MODY mutations. Twelve patients who have uncertain mutation (VUS) were excluded from study for further evaluation. MODY(+) (n:30) patients and T2DM patients (n:25) were compared for clinical and laboratory parameters. Results: In MODY(+) subjects, mutations in GCK (MODY 2) (n:12; 40%) were the most common followed by HNF4A (MODY 1) (n:4; 13.3%). Diabetes diagnosis age was younger in MODY(+) group but not statistically significant. Sixty-six percent of MODY(+) subjects had diabetes history at 3-consecutive generations in their family compared with 28% of T2DM patients statistically significant (p:0.006). Gender, BMI, C-peptide, HbA1c, lipid parameters, creatinine, GFR, microalbuminuria, vitamin D and calcium were not statistically different between the groups. Conclusion: According to present study results, MODY mutation positivity is most probable in young autoantibody (-) diabetic patients diagnosed before 30 years of age, who have first degree family history of diabetes.

Skeletal maturation pattern among Down Syndrome individuals in Benin, City. Nigeria

Background: The assessment of skeletal maturity is important in the timing of orthodontic treatment especially in the modification of dento-facial growth. The use of cervical vertebrae as a method of assessment of skeletal maturity has rarely been used among Down Syndrome. Objective: To assess skeletal maturity among individuals with Down Syndrome using the cervical vertebrae maturation stages. Methods: The study was conducted among 21 Down Syndrome with mean ages of 11.70  1.83 years (males) and 13.64  1.75 years (female); and 21 control individuals with mean ages of 12.00  2.00 years (male), and 13.50  1.90 years (female). The independent t-test and chi-square test were used to determine significant differences among the continuous (age) and categorical variables (cervical vertebrae maturation stages) respectively when matched with gender and chronological age. Fischer exact test was used when an expected frequency presentation was <5. A p-value of < 0.05 was set as statistically significant. Results: Down Syndrome males had delayed maturation at 11 years but accelerated at 12 with early attainment of maturity at 15 years. Down Syndrome female had a delay tendency in skeletal maturation from 11­15 years of age. Overall, Down Syndrome had a 1.242 probability of either having a delay or advancement in skeletal maturation which was not statistically significant. Conclusively, the skeletal maturation pattern between Down syndrome patients and normal individuals was not statistically different. Conclusion: The average timing for commencement of orthodontic treatment especially growth modification for normal individuals can be applied for individuals with Down Syndrome as this present study did not show any statistically significant difference in their overall skeletal maturation.

Progress on effect of vitamin D on fetal and neonatal lung development and its mechanism / 中华围产医学杂志

The role and mechanism of vitamin D in fetal and neonatal lung development and chronic lung diseases development have raised attention in recent years. The placental transfer of vitamin D is the major source of vitamin D to the developing fetus. The lung, as a target organ for vitamin D, has its capacity for vitamin D metabolism and can form biologically active 1,25 dihydroxyvitamin D 3 in a paracrine manner to regulate lung development. Studies have shown that vitamin D is directly involved in the synthesis of lung surfactant proteins and phospholipids and promotes lung maturation such as lung epithelial-mesenchymal interactions and alveolar formation. Furthermore, it regulates immunity and improves placental function, which indirectly affects lung development. Vitamin D deficiency and vitamin D receptor polymorphisms have been found to be detrimental to the development of alveoli, and are associated with respiratory diseases such as neonatal respiratory distress syndrome and bronchopulmonary dysplasia (BPD). Experimental studies in animals have shown that antenatal vitamin D supplementation promotes lung maturation in preterm rats and postnatal vitamin D supplementation can alleviate the hyperoxia-induced inflammatory response in the lung and reduce BPD occurrence. Further high-quality research are needed to explore the dosing, timing, and impact factors of vitamin D for promoting fetal and neonatal lung maturation and clarify the mechanism of its prophylactic and therapeutic action.

MODY11 induced by heterozygous mutations of a novel B lymphocyte kinase / 中华内分泌代谢杂志

To characterize the clinical and molecular features of a patient with maturity-onset diabetes of the young 11(MODY11) and literature review. The patient was a 30-year-old female with hyperglycemia for 2 years. Failure to thrivea, primary amenorrhea, intellectual impairment, and severe hyperlipidemia were present at the same time. A novel mutations of the B lymphocyte kinase gene(BLK) c. 1025C>T(p.A342V) was found in the patient. Literature review revealed that there were more than ten mutation sites in BLK-MODY11. Some of them had hyperglycemia, over weight or systemic lupus erythematosus. To date, the clinical characteristics of the patient, such as growth retardation, primary amenorrhea, and intellectual impairment have not been reported in MODY11. Our clinical report further expands the clinical presentations and variabilities of MODY11.

Discussion on prenatal corticosteroids for fetal lung maturation / 中华围产医学杂志

Prenatal corticosteroid for fetal lung maturation has been widely used in daily practice in obstetrics. However, previous research showed that prenatal corticosteroids may increase the risk of neonatal hypoglycemia and birth weight loss. And it remains controversial regarding the dosage and repeated administration. Based on the guideline "Antenatal corticosteroids to reduce neonatal morbidity and mortality" published by Royal College of Obstetricians and Gynaecologists in February 2022, here we are going to discuss several issues on the usage of prenatal corticosteroids.

Clinical characterization and genetic analysis of 5 Chinese families with glucokinase gene mutations / 中华内分泌代谢杂志

Objective:To summarize the clinical manifestations and molecular genetic characteristics of 5 families with maturity-onset diabetes mellitus of the young 2 (MODY2) caused by glucokinase (GCK) gene mutations.Methods:Clinical data and biochemical results of probands were collected. Peripheral blood samples of probands and first-degree family members were collected and whole exome gene was detected using second-generation sequencing. After comparing against the database, the suspected pathogenic sites were selected for Sanger sequencing verification.Results:All the 5 probands presented with mild fasting hyperglycemia, HbA 1C<7.5%, and no symptoms of thirst, polydipsia or polyuria. There were 6 mutants in 5 families, including M1: c.555delT (P.leu186CysFS Ter19) and M3: c. 263T>A (p.Met88Lys) which haven′t been reported before. During the follow-up, all probands received life-style intervention, except 2 pregnant women who should consider insulin treatment if necessary according to fetal genotypes. Conclusion:Among patients who meet the diagnostic criteria for MODY, MODY2 screening should be performed for children or pregnant women with mild hyperglycemia and family history. GCK gene detection is the gold standard for diagnosis, and accurate diagnosis will be conducive to the selection of appropriate treatment.

Desenvolvimento de um método para avaliação de maturidade digital de instituições de saúde / Development of a method to digital maturity assessment for healthcare organizations / Desarrollo de un método para evaluación de la madurez digital de las instituciones de salud

Objetivos: Desenvolver um método de avaliação de maturidade digital para instituições de saúde. Métodos: Este trabalho caracteriza-se como uma pesquisa exploratória e descritiva; a partir da revisão e da análise crítica de vários métodos, o Índice de Maturidade Digital para Instituições de Saúde (IMDIS) foi desenvolvido e validado por meio da aplicação em 107 instituições de saúde. Resultados: A análise da base resultou em um percentual médio de 44,4% de maturidade digital. Conclusão: As instituições de saúde devem melhor estruturar a sua jornada digital, não apenas adotando as tecnologias digitais, mas também possuindo uma estratégia, mudança de cultura, equipe capacitada, orçamento e apoio da diretoria. O IMDIS pode ser evoluído e servir de base para a criação de outros índices que, concreta e rotineiramente, avaliem a maturidade digital das instituições de saúde e acompanhem a evolução da Saúde Digital.

Objectives: Develop a method to digital maturity assessment for healthcare organizations. Methods: This paper is defined as exploratory and descriptive research. From revision and critical analysis of various methods, the Digital Maturity Index for Healthcare Organization (IMDIS) was developed and validated by its application for 107 healthcare organizations. Results: Database analysis presented 44,4% of percentage average of digital maturity. Conclusion: Healthcare organizations should improve the structure of its digital journey, not only adopting new digital technologies, but also having strategy, cultural change, well-trained team, budget and support from the board. The IMDIS can be evolved and serve as a basis to create other indexes that, concrete and routinely, evaluate digital maturity of healthcare organizations and following up digital health.

Objetivos: Desarrollar un método para evaluación de la madurez digital para instituciones de salud. Métodos: Este trabajo está caracterizado cómo una pesquisa exploratoria y descriptiva. A partir de la revisión y análisis crítico de varios métodos, se desarrolló y validó el Índice de Madurez Digital para Instituciones de Salud (IMDIS) mediante su aplicación en 107 instituciones de salud. Resultados: La análisis de la base de datos resultó en un porcentaje promedio del 44,4% de madurez digital. Conclusiones: Las instituciones de salud deberían estructurar mejor su jornada digital, no solo adoptando tecnologías digitales, sino también teniendo una estrategia, cambio de cultura, equipo calificado, presupuesto y apoyo de la junta directiva. El IMDIS puede evolucionar y servir de base para la creación de otros índices que, de manera concreta y rutinaria, podrían evaluar la madurez digital de las instituciones de salud y monitorear la evolución de la Salud Digital.

Teste de Bender ­ sistema de pontuação gradual: scoping review / Bender test - Gradual scoring system: Scoping review / Test de Bender- sistema de pontuación gradual: scoping review

O teste de Bender avalia a maturidade perceptomotora de crianças a partir da cópia de desenhos. Atualmente no Brasil, o único sistema favorável para correção deste teste é o Sistema de Pontuação Gradual/B-SPG, que considera os erros a partir das distorções da forma. Devido à sua contribuição para a compreensão das dificuldades nas habilidades perceptomotoras apresentadas pela criança e para a elaboração/acompanhamento de intervenções, a presente revisão (scoping review) apresenta um panorama acerca do B-SPG (2005-2020). Foram objeto de análise quantitativa e qualitativa 35 artigos empíricos recuperados do Portal de Periódicos CAPES, Redalyc e Google Scholar. Os resultados indicaram que o B-SPG possui um acúmulo satisfatório de propriedades psicométricas; a sua aplicação em contexto de pesquisa amplia as noções sobre o funcionamento da maturidade perceptomora de crianças brasileiras e que este sistema de correção do Bender também corrobora a prática de psicólogas atuantes nos campos da Psicologia e da Educação

Bender test assesses the perceptomotor maturity of children from drawing reproduction. Currently, in Brazil, the only favorable system for correcting this test is the Gradual Scoring System/B-SPG, which considers errors distortions in drawing reproduction. Due to contribution to the comprehension of the difficulties in the perceptomotor skills presented by the child and the elaboration/follow-up of interventions, this scoping review gives an overview of the B-SPG (2005-2020). It was the object of quantitative and qualitative analysis 35 articles empirical recovered from the CAPES Journal Portal, Redalyc, and Google Scholar. The results indicated that B-SPG has a satisfactory accumulation of psychometric properties; Its application in a research context expands the notions of the functioning of Brazilian children's perceptive maturity and that B-SPG Bender correction system also corroborates the practice of psychologists working in the field of Psychology and Education (AU).

La prueba de Bender evalúa la madurez perceptomotora de niños a través de las copias de dibujos. Actualmente en Brasil, el único sistema disponible para la corrección es el Sistema de Puntuación Gradual/B-SPG, que considera los errores de distorsiones del dibujo. Debido su contribución para la comprensión de las dificultades en la madurez perceptomotora presentada por niños y para la elaboración/acompañamiento de intervenciones, esta revisión (scoping review) presenta un panorama cerca del B-SPG (2005-2020). El analice cuantitativa y cualitativa fue con 35 artículos empíricos recuperados en el Portal de Periódicos CAPES, Redalyc y Google Scholar. Los resultados indicaran que el B-SPG tiene un acumulo satisfactorio de propiedades psicométricas; su aplicación en contexto de pesquisa amplia las nociones sobre el funcionamiento de la madurez perceptomotora de niños brasileños y que este sistema de corrección también corrobora la práctica de psicólogos actuantes en el campo de la Psicología y de la Educación (AU).